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src=\"https:\/\/www.zyneng.com\/wp-content\/uploads\/2023\/01\/1616.jpg\" alt=\"\" width=\"810\" height=\"329\" srcset=\"https:\/\/www.zyneng.com\/wp-content\/uploads\/2023\/01\/1616.jpg 810w, https:\/\/www.zyneng.com\/wp-content\/uploads\/2023\/01\/1616-300x122.jpg 300w, https:\/\/www.zyneng.com\/wp-content\/uploads\/2023\/01\/1616-768x312.jpg 768w, https:\/\/www.zyneng.com\/wp-content\/uploads\/2023\/01\/1616-624x253.jpg 624w\" sizes=\"auto, (max-width: 810px) 100vw, 810px\" \/><\/p>\n<p data-pid=\"jWqoP-__\">\u5e72\u6270\u7ec6\u80de\u5206\u88c2\u53ef\u80fd\u53ea\u662f\u7535\u573a\u6cbb\u7597\u8d77\u6548\u7684\u4e00\u90e8\u5206\u539f\u56e0\u3002\u6700\u8fd1\u7814\u7a76\u53d1\u73b0\uff0c\u7535\u573a\u6cbb\u7597\u7684\u6297\u764c\u6548\u679c\u53ef\u80fd\u8fd8\u6709\u53e6\u5916\u4e24\u79cd\u91cd\u8981\u673a\u7406\u3002<\/p>\n<p data-pid=\"JpZq0zuA\">\u7b2c\u4e00\uff0c<strong>\u589e\u52a0\u7ec6\u80de\u819c\u7684\u901a\u900f\u6027\uff0c\u8ba9\u5176\u5b83\u836f\u7269\u66f4\u597d\u5730\u8fdb\u5165\u764c\u7ec6\u80de\u3002<\/strong><\/p>\n<p data-pid=\"Ms1b3dvt\">\u7531\u4e8e\u7ec6\u80de\u819c\u4e0a\u5f88\u591a\u5206\u5b50\u4e5f\u662f\u5e26\u7535\u7684\uff0c\u901a\u8fc7\u7535\u573a\u5e72\u6270\u80fd\u7834\u574f\u5b83\u7684\u5b8c\u6574\u6027\uff0c\u4ece\u800c\u589e\u52a0\u836f\u7269\u8fdb\u5165\u7ec6\u80de\u7684\u6bd4\u4f8b\u3002\u8fd9\u80fd\u5e2e\u52a9\u89e3\u91ca\u4e3a\u4ec0\u4e48\u7535\u573a\u6cbb\u7597\u80fd\u589e\u5f3a\u5316\u7597\u836f\u7684\u6548\u679c\u3002<\/p>\n<p data-pid=\"HWNgvMCk\">\u7b2c\u4e8c\uff0c<strong>\u5bfc\u81f4\u514d\u75ab\u6027\u7ec6\u80de\u6b7b\u4ea1\uff0c\u589e\u5f3a\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u3002<\/strong><\/p>\n<p data-pid=\"GRxg8vVx\">\u4f53\u5916\u7814\u7a76\u53d1\u73b0\uff0c\u7535\u573a\u6cbb\u7597\u80fd\u5e26\u6765\u4e00\u79cd\u53eb\u201c\u514d\u75ab\u539f\u6027\u7ec6\u80de\u6b7b\u4ea1\uff08Immunogenic Cell Death\uff0cICD\uff09\u201d\u7684\u6548\u679c\uff0c\u4e5f\u5c31\u662f\u6740\u6b7b\u764c\u7ec6\u80de\u7684\u540c\u65f6\uff0c\u6fc0\u6d3b\u4f53\u5185\u7684\u514d\u75ab\u7ec6\u80de\u3002\u6700\u8fd1\u5728\u52a8\u7269\u5b9e\u9a8c\u4e2d\uff0c\u53d1\u73b0\u7535\u573a\u6cbb\u7597\u80fd\u589e\u52a0PD-1\u514d\u75ab\u7597\u6cd5\u6548\u679c\u3002<\/p>\n<p data-pid=\"L2X0fzQ6\">\u7ad9\u5728\u79d1\u7814\u89d2\u5ea6\uff0c\u8fd9\u4e9b\u65b0\u673a\u7406\u90fd\u5f88\u6709\u610f\u601d\uff0c \u503c\u5f97\u7ee7\u7eed\u6df1\u5165\u7814\u7a76\u3002<\/p>\n<p 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data-pid=\"8JAMRKsJ\">\u5f88\u591a\u79d1\u5b66\u5bb6\u7b2c\u4e00\u6b21\u542c\u8bf4\u80bf\u7624\u7535\u573a\u6cbb\u7597\u7684\u65f6\u5019\uff0c\u662f\u975e\u5e38\u6000\u7591\u7684\uff0c\u56e0\u4e3a\u5b83\u5f88\u8de8\u754c\uff0c\u4e0d\u5c5e\u4e8e\u4f20\u7edf\u751f\u7269\u5236\u836f\u7684\u7814\u7a76\u8303\u7574\uff0c\u5f88\u591a\u4eba\u90fd\u770b\u4e0d\u61c2\u3002\u53d1\u660e\u80bf\u7624\u7535\u573a\u6cbb\u7597\u7684Palti\u535a\u58eb\uff0c\u672c\u8eab\u4e5f\u4e0d\u662f\u505a\u836f\u7684\uff0c\u800c\u662f\u751f\u7269\u7269\u7406\u548c\u7535\u751f\u7406\u5b66\u4e13\u5bb6\u3002<\/p>\n<p data-pid=\"E7CAitly\">\u6000\u7591\u5f52\u6000\u7591\uff0c\u597d\u7684\u79d1\u5b66\u5bb6\u559c\u6b22\u8d28\u7591\uff0c\u4f46\u4e5f\u4f1a\u5bf9\u672a\u77e5\u4e8b\u7269\u4fdd\u6301\u5f00\u653e\u5fc3\u6001\u3002\u6700\u540e\u8bf4\u670d\u5927\u5bb6\u7684\uff0c\u8fd8\u662f\u4e34\u5e8a\u8bd5\u9a8c\u548c\u5ba2\u89c2\u6570\u636e\u3002<\/p>\n<p data-pid=\"aBZm2GNa\">2004\u5e74\uff0c\u7b2c\u4e00\u7bc7\u80bf\u7624\u7535\u573a\u6cbb\u7597\u7684\u4e34\u5e8a\u7814\u7a76\u8bba\u6587\u53d1\u8868\uff0c\u52302006\u5e743\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5f00\u542f\uff0c\u518d\u52302009\u5e74\u7b2c\u4e8c\u4e2a3\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5f00\u59cb\uff0c\u968f\u7740\u8bc1\u660e\u5b83\u6709\u6548\u7684\u5ba2\u89c2\u6570\u636e\u79ef\u7d2f\u5f97\u8d8a\u6765\u8d8a\u591a\uff0c\u4ee5\u524d\u8d28\u7591\u7684\u79d1\u5b66\u5bb6\u548c\u533b\u751f\u7ec8\u4e8e\u5f00\u59cb\u5c1d\u8bd5\u7406\u89e3\uff0c\u5e76\u63a5\u7eb3\u8fd9\u79cd\u65b0\u578b\u6cbb\u7597\u624b\u6bb5\u3002<\/p>\n<p data-pid=\"onuctjll\">\u7531\u4e8e\u5f88\u65b0\u9896\uff0c\u80bf\u7624\u7535\u573a\u6cbb\u7597\u8fd8\u6709\u5f88\u591a\u7814\u7a76\u9700\u8981\u505a\u3002<\/p>\n<p data-pid=\"5khE0Wk6\">\u6bd4\u5982\uff0c\u8fd8\u6709\u4ec0\u4e48\u522b\u7684\u80bf\u7624\u7c7b\u578b\u80fd\u4ece\u4e2d\u83b7\u76ca\uff1f<\/p>\n<p data-pid=\"HqT-1OX2\">\u80bf\u7624\u7535\u573a\u4e4b\u6240\u4ee5\u5148\u88ab\u5c1d\u8bd5\u7528\u4e8e\u6076\u6027\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u548c\u6076\u6027\u80f8\u819c\u95f4\u76ae\u7624\uff0c\u662f\u56e0\u4e3a\u65e9\u671f\u7814\u7a76\u53d1\u73b0\u8fd9\u4e24\u7c7b\u764c\u7ec6\u80de\u5bf9\u7535\u573a\u6cbb\u7597\u90fd\u975e\u5e38\u654f\u611f\u3002\u7406\u8bba\u4e0a\uff0c\u80bf\u7624\u7535\u573a\u6cbb\u7597\u5e94\u8be5\u662f\u4e00\u79cd\u5e7f\u8c31\u7684\u6297\u764c\u65b9\u6cd5\u3002\u5728\u4f53\u5916\u5b9e\u9a8c\u4e2d\uff0c\u5b83\u5bf9\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u80f0\u817a\u764c\u3001\u5375\u5de2\u764c\u7b49\u4e5f\u90fd\u5c55\u73b0\u4e86\u7597\u6548\u3002\u76ee\u524d\u670920\u591a\u9879\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u5982\u706b\u5982\u837c\u5730\u5f00\u5c55\uff0c\u6709\u5174\u8da3\u7684\u53ef\u4ee5\u770b\u770b\u3002\uff08<a class=\" external\" href=\"https:\/\/link.zhihu.com\/?target=https%3A\/\/clinicaltrials.gov\/ct2\/results%3Fcond%3D%26term%3DTTFields\" target=\"_blank\" rel=\"nofollow noopener noreferrer\" data-za-detail-view-id=\"1043\"><span class=\"invisible\">https:\/\/<\/span><span class=\"visible\">clinicaltrials.gov\/ct2\/<\/span><span class=\"invisible\">results?cond=&amp;term=TTFields<\/span><\/a>\uff09<\/p>\n<p data-pid=\"ykxJSliG\">\u6bd4\u5982\uff0c\u4e3a\u4ec0\u4e48\u4e0d\u540c\u764c\u7ec6\u80de\u9002\u7528\u7684\u80bf\u7624\u7535\u573a\u9891\u7387\u4e0d\u540c\uff1f<\/p>\n<p 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data-pid=\"mOnxMAoq\">\u76f8\u5bf9\u5355\u72ec\u4f7f\u7528\uff0c\u6211\u66f4\u76f8\u4fe1\u80bf\u7624\u7535\u573a\u6cbb\u7597\u7684\u4ef7\u503c\u4e3b\u8981\u5728\u8054\u5408\u6cbb\u7597\u4e2d\u3002\u7531\u4e8e\u5b83\u5177\u6709\u591a\u79cd\u4f5c\u7528\u673a\u7406\uff0c\u5305\u62ec\u5e72\u6270\u7ec6\u80de\u5206\u88c2\uff0c\u589e\u52a0\u7ec6\u80de\u819c\u901a\u900f\u6027\uff0c\u5f15\u8d77\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u7b49\uff0c\u56e0\u6b64\u7406\u8bba\u4e0a\u53ef\u80fd\u548c\u5316\u7597\u836f\uff0c\u9776\u5411\u836f\uff0c\u514d\u75ab\u836f\uff0c\u751a\u81f3\u653e\u7597\u8054\u5408\u4f7f\u7528\uff0c\u4ea7\u751f\u534f\u540c\u6548\u5e94\u3002<\/p>\n<p data-pid=\"eCXloJw4\">\u7535\u573a\u6cbb\u7597\u5230\u5e95\u4e34\u5e8a\u662f\u600e\u4e48\u8d77\u6548\u7684\uff1f\u600e\u4e48\u8054\u7528\u6548\u679c\u6700\u597d\uff1f\u6027\u4ef7\u6bd4\u6700\u9ad8\uff1f\u8fd9\u4e9b\u7b54\u6848\u4e0d\u4ec5\u53ef\u4ee5\u63a2\u7d22\u672a\u77e5\u79d1\u5b66\u4e16\u754c\uff0c\u8fd8\u80fd\u5f15\u5bfc\u6211\u4eec\u5f00\u53d1\u66f4\u597d\u7684\u7ec4\u5408\u7597\u6cd5\u3002<\/p>\n<p data-pid=\"8Ll-DFmC\">\u603b\u4e4b\uff0c\u597d\u620f\u624d\u521a\u521a\u5f00\u59cb\u3002\u671f\u5f85\u66f4\u591a\u7684\u597d\u6d88\u606f\uff01<\/p>\n<p data-pid=\"byquZYBI\"><strong>\u81f4\u656c\u751f\u547d\uff01<\/strong><\/p>\n<p data-pid=\"71kJfTJu\">\u53c2\u8003\u6587\u732e\uff1a<\/p>\n<p data-pid=\"gps2aLyf\">1. NovoTTF-100A versus physician&#8217;s choice chemotherapy in recurrent glioblastoma: a randomised phase III trial of a novel treatment modality. Eur J Cancer, 2012. 48(14): p.2192-202.<\/p>\n<p data-pid=\"hfWec-1v\">2. Effect of Tumor-Treating Fields Plus Maintenance Temozolomide vs Maintenance Temozolomide Alone on Survival in Patients With Glioblastoma: A Randomized Clinical Trial. JAMA,2017. 318(23): p. 2306-2316.<\/p>\n<p data-pid=\"kWQhy0zc\">3. Tumor-treating fields (TTFields) induce immunogenic cell death resulting in enhanced antitumor efficacy when combined with anti-PD-1 therapy. Cancer Immunol Immunother. 2020 Mar 6.<\/p>\n<p data-pid=\"ckqTbSMV\">4. Tumor treating fields increases membrane permeability in glioblastoma cells. Cell Death Discov. 2018 Dec 5;4:113.<\/p>\n<p data-pid=\"PqDNls7L\">5. Tumour Treating Fields in combination with pemetrexed and cisplatin or carboplatin as first-line treatment for unresectable malignant pleural mesothelioma (STELLAR): a multicentre, single-arm phase 2 trial. Lancet Oncol. 2019 Dec;20(12):1702-1709.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\uff08\u4e00\uff09 \u75ab\u60c5\u671f\u95f4\uff0c\u4e2d\u56fd\u5bf9\u65b0\u578b\u6297\u764c\u7597\u6cd5\u7684\u5ba1\u6279\u6ca1\u6709\u505c\u6ede\u30022020\u5e74\u7b2c\u4e00\u5b63\u5ea6\uff0c\u5df2\u7ecf\u6709\u591a\u4e2a\u6297\u764c\u9776\u5411\u548c\u514d\u75ab\u65b0\u836f\u5728\u4e2d\u56fd\u83b7\u6279\u4e0a\u5e02\uff0c\u9488\u5bf9\u5305\u62ec\u80c3\u764c\u3001\u80ba\u764c\u3001\u809d\u764c\u3001\u4e73\u817a\u764c\u3001\u76ae\u80a4\u764c\u7b49\u591a\u4e2a\u9002\u5e94\u75c7\u3002 \u4f46\u80bf\u7624\u6cbb\u7597\u662f\u4e2a\u7efc\u5408\u5de5\u7a0b\uff0c\u9664\u4e86\u836f\uff0c\u8fd8\u6709\u5176\u5b83\u6709\u6548\u65b9\u6cd5\u3002\u8fd9\u4e0d\uff0c\u5c31\u5728\u8fd9\u4e24\u5929\uff0c\u80bf\u7624\u7535\u573a\u6cbb\u7597\u4e5f\u9996\u6b21\u5728\u4e2d\u56fd\u5927\u9646\u83b7\u6279\u4e0a\u5e02\u4e86\uff01 \u4f5c\u4e3a\u4e00\u79cd\u5168\u65b0\u7684\u6297\u764c\u624b\u6bb5\uff0c\u80bf\u7624\u7535\u573a\u6cbb\u7597\u5230\u5e95\u662f\u4ec0\u4e48\uff1f\u9002\u7528\u4e8e\u54ea\u4e9b\u60a3\u8005\uff1f\u4f5c\u7528\u673a\u7406\u53c8\u662f\u4ec0\u4e48\u5462\uff1f \u80bf\u7624\u7535\u573a\u6cbb\u7597\u7684\u82f1\u6587\u53ebTumor Treating Fields\uff0c\u7f29\u5199\u4e3aTTFields\u3002\u8fd9\u6b21\u4e0a\u5e02\u7684\u4ea7\u54c1\u662f\u518d\u9f0e\u533b\u836f\u5f15\u8fdb\u7684\u4e00\u79cd\u53ef\u7a7f\u6234\u8bbe\u5907\uff0c\u5546\u54c1\u540d\u53eb\u201c\u7231\u666e\u76fe\uff08Optune\uff09\u201d\u3002 \u65e9\u57282011\u5e74\uff0c\u5b83\u5df2\u7ecf\u5728\u7f8e\u56fd\u83b7\u6279\u4e0a\u5e02\uff0c\u6700\u521d\u662f\u7528\u4e8e\u6076\u6027\u8111\u80f6\u8d28\u7624\u7684\u6cbb\u7597\u30022019\u5e74\u80bf\u7624\u7535\u573a\u6cbb\u7597\u83b7\u6279\u65b0\u7684\u9002\u5e94\u75c7\uff0c\u7528\u4e8e\u6cbb\u7597\u6076\u6027\u80f8\u819c\u95f4\u76ae\u7624\uff0c\u5546\u54c1\u540d\u4e3aOptune 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